Benchmarks für die Treibhausgasemissionen der Gebäudekonstruktion

BENCHMARKS FÜR DIE TREIBHAUSGASEMISSIONEN DER GEBÄUDEKONSTRUKTION Benchmarks für die Treibhausgasemissionen der Gebäudekonstruktion / Braune, Anna (Rights reserved) ( -

Management, archiving and provision of aerodynamic and aeroelastic data - A new database concept

In order to share and to improve the usage of high-quality measurement data, a new web ap-plication called "AeDb" (Aeroelastic Database) in combination with a measurement database is presented. AeDb can be used to manage, archive and provide aerodynamic and aeroelastic windtunnel data, numerical simulations, and other project related files such as videos and papers. When flowing through the database the data can be filtered and searched, for example to investigate measurement points with specific parameters. In addition an easy access to the data via Python or MATALB is included as well as the possibility to intuitively generate a new measurement campaign. It also enables a more effective and user-friendly execution of experiments through measurement automatization what in detail means that a measurement point only can be triggered if all persons are "ready" (multi-person-agreement). After the measurement the data gets automatically uploaded and synchronized to the database. For this purpose, this paper first describes how measurement campaigns have been prepared and executed in the past. Afterwards, the requirements that arise due to the age of digitalization and the increasing amount of data will be discussed, followed by a description of the AeDb. Finally, an overview of the used hardware and software is given

Costs and underuse of insulin and diabetes supplies: Findings from the 2020 T1 International cross-sectional web-based survey

Aims: To investigate self-reported out-of-pocket expenses (OoPE) associated with insulin and diabetes supplies for people living with type 1 diabetes (T1D) worldwide. Methods: A web-based, cross-sectional survey was conducted from August to December 2020. The analysis included comparisons between responses from countries with no, partial, and full healthcare coverage. Results: 1,066 participants from 64 countries took part in the study. ~25% of respondents reported having underused insulin at least once within the last year due to perceived cost. A significant correlation was observed between OoPEs and reported household income for respondents with partial healthcare coverage. 63.2% of participants reported disruption of insulin supplies and 25.3% reported an increase of prices related to the COVID-19 pandemic. Conclusions: This study confirms previous reports of ~25% of people in the United States with T1D using less insulin and/or fewer supplies at least once in the last year due to cost, a trend associated with the extent of healthcare coverage. Similar trends were observed in some middle/low income countries. Moreover, patients reported an increase in insulin prices and disruption of supplies during the COVID-19 pandemic. This study highlights the importance of self-reported OoPEs and its association with underuse/rationing of insulin.Arnold VenturesCenter for Translational Science and Trainin

Ihr Weg zum klimaneutralen Gebäude

IHR WEG ZUM KLIMANEUTRALEN GEBÄUDE Ihr Weg zum klimaneutralen Gebäude / Braune, Anna (Rights reserved) ( -

Listening carefully: increased perceptual acuity for species discrimination in multispecies signalling assemblages

Communication is a fundamental component of evolutionary change because of its role in mate choice and sexual selection. Acoustic signals are a vital element of animal communication and sympatric species may use private frequency bands to facilitate intraspecific communication and identification of conspecifics (acoustic communication hypothesis, ACH). If so, animals should show increasing rates of misclassification with increasing overlap in frequency between their own calls and those used by sympatric heterospecifics. We tested this on the echolocation of the horseshoe bat, Rhinolophus capensis, using a classical habituation-dishabituation experiment in which we exposed R. capensis from two phonetic populations to echolocation calls of sympatric and allopatric horseshoe bat species (Rhinolophus clivosus and Rhinolophus damarensis) and different phonetic populations of R. capensis. As predicted by the ACH, R. capensis from both test populations were able to discriminate between their own calls and calls of the respective sympatric horseshoe bat species. However, only bats from one test population were able to discriminate between calls of allopatric heterospecifics and their own population when both were using the same frequency. The local acoustic signalling assemblages (ensemble of signals from sympatric conspecifics and heterospecifics) of the two populations differed in complexity as a result of contact with other phonetic populations and sympatric heterospecifics. We therefore propose that a hierarchy of discrimination ability has evolved within the same species. Frequency alone may be sufficient to assess species membership in relatively simple acoustic assemblages but the ability to use additional acoustic cues may have evolved in more complex acoustic assemblages to circumvent misidentifications as a result of the use of overlapping signals. When the acoustic signal design is under strong constraints as a result of dual functions and the available acoustic space is limited because of co-occurring species, species discrimination is mediated through improved sensory acuity in the receiver

Ökobilanz-Benchmarks für Immobilien: Methode zur Entwicklung zukunftsorientierter Kennwerte für eine lebenszyklusbasierte Bewertung der ökologischen Nachhaltigkeit von Immobilien

Die Dissertation stellt eine methodische Basis zur Entwicklung von zukunftsorientierten Benchmarks für eine lebenszyklusbasierte Bewertung der ökologischen Nachhaltigkeit von Immobilien zur Verfügung. Hierzu wurde eine Methode entwickelt, die als Basis zwei prinzipielle Konzepte verbindet: Die Grundlagen der Methodik von Umweltkennzahlen-Managementsystemen zur Formulierung und Steuerung von Zielen und Gebäude-Ökobilanz-Kennzahlen zur Ermittlung lebenszyklusumfassender ökologischer Leistungswerte für Immobilien. Die Methode wird anhand eines Beispiels demonstriert. Die Methode hilft politischen Entscheidungsträgern sowie öffentlichen und privaten Organisationen ein Vorgehen zu entwickeln, wie langfristige ökologische Ziele für den Bau- und Immobiliensektor gesetzt und diese in Form konkreter Benchmarks für Immobilien umgesetzt und verfolgt werden können

Leitfaden zum Einsatz der Ökobilanzierung

LEITFADEN ZUM EINSATZ DER ÖKOBILANZIERUNG Leitfaden zum Einsatz der Ökobilanzierung / Braune, Anna (Rights reserved) ( -

Effect of Endothelial Culture Medium Composition on Platelet Responses to Polymeric Biomaterials

Near-physiological in vitro thrombogenicity test systems for the evaluation of blood-contacting endothelialized biomaterials requires co-cultivation with platelets (PLT). However, the addition of PLT has led to unphysiological endothelial cell (EC) detachment in such in vitro systems. A possible cause for this phenomenon may be PLT activation triggered by the applied endothelial cell medium, which typically consists of basal medium (BM) and nine different supplements. To verify this hypothesis, the influence of BM and its supplements was systematically analyzed regarding PLT responses. For this, human platelet rich plasma (PRP) was mixed with BM, BM containing one of nine supplements, or with BM containing all supplements together. PLT adherence analysis was carried out in six-channel slides with plasma-treated cyclic olefin copolymer (COC) and poly(tetrafluoro ethylene) (PTFE, as a positive control) substrates as part of the six-channel slides in the absence of EC and under static conditions. PLT activation and aggregation were analyzed using light transmission aggregometry and flow cytometry (CD62P). Medium supplements had no effect on PLT activation and aggregation. In contrast, supplements differentially affected PLT adherence, however, in a polymer- and donor-dependent manner. Thus, the use of standard endothelial growth medium (BM + all supplements) maintains functionality of PLT under EC compatible conditions without masking the differences of PLT adherence on different polymeric substrates. These findings are important prerequisites for the establishment of a near-physiological in vitro thrombogenicity test system assessing polymer-based cardiovascular implant materials in contact with EC and PLT